This study presents a comprehensive bibliometric analysis aimed at exploring the scientific landscape of quality assurance in healthcare. Utilizing data from the Web of Science Core Collection, an initial pool of 1,845 records was systematically screened using the PRISMA flow diagram, resulting in 366 English-language, open-access research articles published between 2000 and 2024. VOSviewer software was employed to visualize and analyze co-authorship networks, keyword co-occurrence, national collaborations, and bibliographic coupling. The findings demonstrate a notable increase in the number of publications and citations after 2015, indicating growing academic and policy interest in healthcare quality assurance. Jeffrey Braithwaite was identified as the most prolific author, while the United States emerged as the leading contributor in terms of national research output. Frequently occurring keywords such as “Quality Assurance,” “Patient Safety,” “Quality Improvement,” and “Healthcare” highlight the field’s thematic emphasis on safety, efficiency, and system performance. In terms of scholarly influence, Jaffe (2013) ranked highest in bibliographic coupling, and JAMA – Journal of the American Medical Association was the most cited journal. Overall, this bibliometric study provides valuable information on the development, thematic orientations and collaborative structure of research in healthcare quality assurance, highlighting the interdisciplinary development of this field and its strategic importance within initiatives towards a global quality assurance focus.